I have the following script, the x hotkey can only be fired if active has 1, this is as desired:

#singleinstance, force
active := 1

Hotkey If, (active)
#If (active)
x::
tooltip, x is pressed
return
#If

z::
;disable the Hotkey If, (!MG_Active) condition for "x"s
return

Later on during the scripts life time need to remove this Hotkey If, <epression> equation from the script, as the scripts code entirely consists of the following, thus x hotkey always fires regardless of what active has:

#singleinstance, force
active := 1

x::
tooltip, x is pressed
return

z::
;disable the Hotkey If, (!MG_Active) condition for "x"s
return

While writting this, I realised I could just use z to set active to 0, but I really need to figure how this aspect of the hotkey command works. I spent all day stuck on this.