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Applying an affine transformation using OpenCV, skimage, and scipy returns different results

I’d like to apply a homography matrix to transform a very large (50kx50k pixels). On the small scale, both cv2 and skimage apply a matrix in a predictable way. However, SciPy (which has large image support in Dask Image) doesn’t transform the image in a predictable way and I can’t work out why. If I could get SciPy to work, I can easily affine transform my large image with Dask.