I am looking for which of the following code examples are the preferred method to set and clear flags in C and why.

int main()
{
  #define FLAG5 0x10 // 0001 0000
  #define SET_Flag5     Flags |= FLAG5
  #define CLR_Flag5     Flags &= ~FLAG5

  SET_Flag5;
  CLR_Flag5;
 }

or this method

int main()
{
 #define Set_Flag5    Flags = (Flags & 0xffef) | 1  << 4  
 #define Clr_Flag5    Flags = (Flags & 0xffef) | 0  << 4  

 Set_Flag5;
 Clr_Flag5;
}

Thanks Roy