At some point I needed to resize the (Windows) desktop icons.
So I adjusted the relevant windows registry items, for both icon size and spacing, as widely described elsewhere. Specifically:

# Icon Spacing:
# HKCU:Control PanelDesktopWindowMetrics
# Type in a value between -480 to -2730
IconSpacing         -1400
IconVerticalSpacing -1400

# Desktop Icon size:
# HKCU:SoftwareMicrosoftWindowsShellBags1Desktop 
# ComputerHKEY_CURRENT_USERSoftwareMicrosoftWindowsShellBags1Desktop
# IconSize 0x20  (32)
IconSize 0x18

(I have no idea why MS is incapable to provide a Settings option for this!?)

However, after a Windows update and reboot, the desktop icons came up completely jumbled.
I checked the registry items and they were intact.

So I resized the desktop icons using [CTRL] + <mouse scroll up/down> (while pointer on empty desktop area), after a few scrolls, suddenly the correct icon layout was re-instated.

Great, but after reboot, they were all jumbled up again!

What’s going on, and how can I make my current desktop icon size and layout, permanent?