I know how to play a wav file with python_vlc,
e.g (here to play an audio stream)

import vlc

instance=vlc.Instance('--input-repeat=-1','--fullscreen')
player=instance.media_player_new()
url="my url"
media=instance.media_new(url)
player.set_media(media)
player.play()

but I didn’t find any command to play it in mono mode.
Any help appreciated.

I’ve asked the support of my hardware and searched among stackoverflow questions.