I need to draw several biomarker changes by Date on one graph, but biomarker samples were measured in different dates and different times, so for example:

data = {
    'PatientID': [244651, 244651, 244651, 244651, 244652, 244653, 244651],
    'LocationType': ['IP', 'IP', 'OP', 'IP', 'IP', 'OP', 'IP'],
    'Date': ['2023-01-01', '2023-01-02', '2023-01-03', '2023-01-04', '2023-01-01', '2023-01-01', '2023-01-05'],
    'Biomarker1': [1.1, 1.2, None, 1.4, 2.1, 3.1, 1.5],
    'Biomarker2': [2.1, None, 2.3, 2.4, 3.1, 4.1, 2.5],
    'Biomarker3': [3.1, 3.2, 3.3, None, 4.1, 5.1, 3.5]
}

to draw a graph:

# Set the date as the index
filtered_df.set_index('Date', inplace=True)

# Plot all biomarkers
plt.figure(figsize=(12, 8))

# Loop through each biomarker column to plot
for column in filtered_df.columns:
    if column not in ['PatientID', 'LocationType']:
        plt.plot(filtered_df.index, filtered_df[column], marker='o', linestyle='-', label=column)

here is my output:
Biomarker change over time

I need all the point of one biomarkers to be connected just with the line. I cannot use interpolate, the points should be just connected with line.

How do I do it?
Please, help!

I tried to interpolate, but it creates new points, I don’t need new points.